Lisinopril generic for prevention of ischemic heart disease and the reduction in risk of hemorrhagic stroke. Journal the American College of Cardiology. Vol. 30, no.11, pp 439-442, 2004. The authors, led by Thomas V. Smith, M.D. of the University Pittsburgh School Medicine in Pennsylvania, reported on a randomized placebo-controlled trial comparing the use of salsalate and simvastatin to prevent all-cause mortality in an adult population of patients without a history thromboembolism. Among total of 20,638 patients, there was no significant difference between the two drugs in any of the four major endpoints studied in the trial (atherosclerotic cardiovascular disease, all-cause mortality, revascularization and risk of major bleeding). However, when the two drugs were Lisinopril 2.5mg $113.04 - $0.42 Per pill compared as monotherapy, the overall all-cause mortality risk difference between the two groups was reduced to 22% (no significant difference in the risk of major bleeding or mortality from ischemic hemorrhagic stroke), online pharmacy programs in canada and the all-cause, ischemic stroke mortality difference was almost halved. Salsalate may be an option in patients who have been randomized for other medical therapies that have failed. In terms of risk, simvastatin, an anti-platelet drug, reduces the risk of stroke and all-cause death, but this effect may be partially mitigated by salsalate as noted above. However, the risk of stroke is lessened with use of salsalate than simvastatin because the latter drug reduces risk of thromboembolic stroke but does not decrease other blood clots. A randomized controlled trial called the RACPAC has already been completed, to evaluate an antiplatelet agent, salsalate, in patients who have had a non-haemorrhagic stroke (angina pectoris). The trial results are set to be published in December. Dr. Smith, who has authored five books on stroke prevention, wrote a critical review of the study entitled RACPAC and Case Against Salsalate in September 2002 on the Web site of American Heart Association. In a report issued March 2005, Stroke, a publication of the American College Cardiology, reported on two other ongoing studies evaluating salsalate in association with aspirin and clopidogrel as monotherapy with warfarin (Coumadin®) a second-line agent. A randomized placebo-controlled trial and two follow-on phase III studies were conducted as part of the phase I/II studies to evaluate salsalate in patients with acute ischemic stroke and myocardial infarction. (A non-fatal infarction is a complication of stroke.) An analysis patients in this cohort showed significant improvements in stroke outcomes with the use of salsalate. authors, led by Thomas V. Smith, M.D., of the University Pittsburgh School Medicine in Pennsylvania, reported: "Among patients who received salsalate 200 mg [in the first two weeks], stroke rates were reduced by 43% at 24 hours and by 37% at three days relative to placebo-treated subjects. Overall, 92% of salsalate-treated patients were in a clinically meaningful recovery time interval (mean, 36 hours), with a significant and clinically meaningful reduction in stroke rate patients within that time interval versus placebo." The authors also stated that "Salsalate reduced the most severe and lethal stroke outcomes, including myocardial infarction, pulmonary embolism and stroke death, in a dose-dependent manner." The authors suggested that this finding what is the generic drug for lisinopril could be indicative of a direct pathophysiological basis for the stroke protective effects of s.
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